Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer.

doi:10.1200/JCO.2012.46.5740

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Article

Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2013

Iyer Gopa, Al-Ahmadie Hikmat, Schultz Nikolaus, Hanrahan Aphrothiti J, Ostrovnaya Irina, Balar Arjun V, Kim Philip H, Lin Oscar, Weinhold Nils, Sander Chris, Zabor Emily C, Janakiraman Manickam, Garcia-Grossman Ilana R, Heguy Adriana, Viale Agnes, Bochner Bernard H, Reuter Victor E, Bajorin Dean F, Milowsky Matthew I, Taylor Barry S, Solit David B

Abstract excerpt

PURPOSE: We sought to define the prevalence and co-occurrence of actionable genomic alterations in patients with high-grade bladder cancer to serve as a platform for therapeutic drug discovery. PATIENTS AND METHODS: An integrative analysis of 97 high-grade bladder tumors was conducted to identify actionable drug targets, which are defined as genomic alterations that have been clinically validated in another...

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PMID: 23897969
DOI: 10.1200/JCO.2012.46.5740
PMCID: PMC3753703

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