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Article

Quantitative proteomic analysis reveals unique Hsp90 cycle-dependent client interactions.

Genetics - 5 Jun 2024

Rios Erick I, Gonçalves Davi, Morano Kevin A, Johnson Jill L

Abstract excerpt

Hsp90 is an abundant and essential molecular chaperone that mediates the folding and activation of client proteins in a nucleotide-dependent cycle. Hsp90 inhibition directly or indirectly impacts the function of 10-15% of all proteins due to degradation of client proteins or indirect downstream effects. Due to its role in chaperoning oncogenic proteins, Hsp90 is an important drug target. However, compounds that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38606935
DOI: 10.1093/genetics/iyae057
PMCID: PMC11151932

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