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Epigenetic and polygenic contributions to body mass index: a validation study of predictive models.

Clinical epigenetics - 6 Mar 2026

Marszałek Kamila, Wróbel Maria, Subramanian Balakrishnan, Jaworska Krystyna, Pisarek-Pacek Aleksandra, Piniewska-Róg Danuta, Makiel Karol, Suder Agnieszka, Michalczyk Małgorzata, Wysocka Bożena, Sitek Aneta, Spólnicka Magdalena, Ossowski Andrzej, Branicki Wojciech, Pośpiech Ewelina

Abstract excerpt

Body mass index (BMI) has a notable genetic component, yet the majority of genetic variants remain elusive. Their identification may be hindered as weight also stems from exogenous factors and may be shaped by lifestyle influences. Since DNA methylation is partially controlled by genes and also captures environmental exposures, epigenetic biomarkers have been successfully employed in BMI prediction. In this...

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PMID: 41792832
DOI: 10.1186/s13148-025-02040-6
PMCID: PMC13220415

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