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Article

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations.

American journal of human genetics - 2 Jul 2015

Shah Sonia, Bonder Marc J, Marioni Riccardo E, Zhu Zhihong, McRae Allan F, Zhernakova Alexandra, Harris Sarah E, Liewald Dave, Henders Anjali K, Mendelson Michael M, Liu Chunyu, Joehanes Roby, Liang Liming, Levy Daniel, Martin Nicholas G, Starr John M, Wijmenga Cisca, Wray Naomi R, Yang Jian, Montgomery Grant W, Franke Lude, Deary Ian J, Visscher Peter M

Abstract excerpt

We tested whether DNA-methylation profiles account for inter-individual variation in body mass index (BMI) and height and whether they predict these phenotypes over and above genetic factors. Genetic predictors were derived from published summary results from the largest genome-wide association studies on BMI (n ∼ 350,000) and height (n ∼ 250,000) to date. We derived methylation predictors by estimating...

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Identifiers

PMID: 26119815
DOI: 10.1016/j.ajhg.2015.05.014
PMCID: PMC4572498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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