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Article

Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution.

American journal of human genetics - 7 Dec 2017

Abadi Arkan, Alyass Akram, Robiou du Pont Sebastien, Bolker Ben, Singh Pardeep, Mohan Viswanathan, Diaz Rafael, Engert James C, Yusuf Salim, Gerstein Hertzel C, Anand Sonia S, Meyre David

Abstract excerpt

A growing number of single-nucleotide polymorphisms (SNPs) have been associated with body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci are uniform across the BMI distribution remains unclear. We studied the effects of 37 BMI-associated SNPs in 75,230 adults of European ancestry across BMI percentiles by using conditional quantile regression (CQR) and meta-regression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29220676
DOI: 10.1016/j.ajhg.2017.10.007
PMCID: PMC5812888

Genes

FTO
FANCL
GIPR
IGF1
PCSK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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