Article
Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization.
BMC medicine - 6 Mar 2026
Bouka Martina, Nimptsch Katharina, Pham Thu Thi, Bouras Emmanouil, Kanellopoulou Afroditi, Phipps Amanda I, Van Guelpen Bethany, Brenner Hermann, Li Li, Le Marchand Loïc, Tsilidis Konstantinos K, Pischon Tobias
Abstract excerpt
BACKGROUND: Despite significant progress in identifying risk factors for colorectal cancer (CRC), factors influencing survival in people with CRC remain less understood. Pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) have been implicated in cancer progression and may influence CRC outcomes. We investigated associations between genetically predicted levels of IL-6 and...
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