Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

To unveil the causal relationship between immunophenotypes and colorectal cancer using two-sample bidirectional Mendelian randomization and mediation analyses.

Medicine - 10 Jul 2026

Zhang Yi, Fei Bingyuan, Fang Xuedong, Tian Suyan

Abstract excerpt

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. The mechanisms underlying this trend are not yet fully understood. This study aimed to examine the potential role of genetically predicted immunophenotypes in the development of CRC. A two-sample bidirectional Mendelian randomization study was conducted to explore the relationship between 731 genetically predicted immune cells and CRC....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to CD4 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Immunophenotyping

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 42432892
DOI: 10.1097/MD.0000000000049769
PMCID: PMC13363119

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

To unveil the causal relationship between immunophenotypes and colorectal cancer using two-sample bidirectional Mendelian randomization and mediation analyses.PMID 42432892Read ↗

Causal impacts of 731 immunocyte phenotypes on colorectal cancer-evidence from a bidirectional two-sample Mendelian randomization.Semantic proximity Read ↗

Immune cells as mediators in lipids-colorectal cancer risk: A Mendelian randomization study.Semantic proximity Read ↗

Causal effects and metabolites mediators between immune cell and risk of colorectal cancer: a Mendelian randomization study.Semantic proximity Read ↗

Gut microbiota, immune cell, colorectal cancer association mediators: a Mendelian randomization studySemantic proximity Read ↗

Causal role of immune cells in digestive system cancers: A Mendelian randomization studySemantic proximity Read ↗

Mendelian randomization investigation of the causal association between circulating cytokines and colorectal cancerSemantic proximity Read ↗

Unraveling the causal role of immune cells in gastrointestinal tract cancers: insights from a Mendelian randomization studySemantic proximity Read ↗

Association between immune cell attributes, serum metabolites, inflammatory protein factors, and colorectal cancer: A Mendelian randomization study.Semantic proximity Read ↗

Exploring potential causal associations between autoimmune diseases and colorectal cancer using bidirectional Mendelian randomizationSemantic proximity Read ↗

Immune cells mediate the causal relationship between uveitis and colorectal cancer via Mendelian randomization analysis.Semantic proximity Read ↗

Causal Relationship between Peripheral Immune Cell Counts and Inflammatory Bowel Diseases: A Bi-directional Two-sample Mendelian Randomization StudySemantic proximity Read ↗

Evaluating the association between immunological proteins and common intestinal diseases using a bidirectional two-sample Mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.