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Article

The Sex- and Age-Specific Association of AANAT Gene Polymorphisms With the Risk of Major Depressive Disorder in the Chinese Population.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Apr 2026

Peng Qiuju, Kong Yanying, Dai Tao, Liu Duoduo, Liang Yumin, Xie Guibo, Wen Yuguan, Li Rui, Yan Yuan

Abstract excerpt

The Arylalkylamine N-Acetyltransferase (AANAT) serves as the rate-limiting enzyme in melatonin biosynthesis; dysregulation of the melatonin system has been implicated in major depressive disorder (MDD). This study aimed to investigate the associations between the AANAT gene polymorphisms (rs4238989 and rs3760138) and MDD risk in a Chinese population. A case-control study was conducted involving 502 MDD patients...

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Identifiers

PMID: 41789583
DOI: 10.1002/jdn.70101

Genes

AANAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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