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Article

Resequencing and association analysis of arylalkylamine N-acetyltransferase (AANAT) gene and its contribution to major depression susceptibility.

Journal of pineal research - 1 Aug 2010

Soria Virginia, Martínez-Amorós Erika, Escaramís Geòrgia, Valero Joaquín, Crespo José M, Gutiérrez-Zotes Alfonso, Bayés Mònica, Martorell Lourdes, Vilella Elisabet, Estivill Xavier, Menchón José M, Gratacòs Mònica, Urretavizcaya Mikel

Abstract excerpt

Circadian rhythms disruptions, including abnormalities of circadian phase position and melatonin secretion, have been described in major depression (MD). Arylalkylamine N-acetyltransferase (AANAT) is a key enzyme of the melatonin pathway involved in circadian oscillations of melatonin levels. We assessed the contribution of AANAT gene variability to susceptibility to MD considering common and rare genetic...

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Identifiers

PMID: 20459461
DOI: 10.1111/j.1600-079X.2010.00763.x

Genes

AANAT
MAF

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