Article
Improvement in neoantigen prediction via integration of RNA sequencing data for variant calling.
Frontiers in immunology - 1 Jan 2023
Nguyen Bui Que Tran, Tran Thi Phuong Diem, Nguyen Huu Thinh, Nguyen Thanh Nhan, Pham Thi Mong Quynh, Nguyen Hoang Thien Phuc, Tran Duc Huy, Nguyen Vy, Tran Thanh Sang, Pham Truong-Vinh Ngoc, Le Minh-Triet, Phan Minh-Duy, Giang Hoa, Nguyen Hoai-Nghia, Tran Le Son
Abstract excerpt
Introduction: Neoantigen-based immunotherapy has emerged as a promising strategy for improving the life expectancy of cancer patients. This therapeutic approach heavily relies on accurate identification of cancer mutations using DNA sequencing (DNAseq) data. However, current workflows tend to provide a large number of neoantigen candidates, of which only a limited number elicit efficient and immunogenic T-cell...
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