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Article

Could vector-derived cadherin mimicry contribute to pemphigus vulgaris? An immunogenetic and in silico study involving HLA-DRB104:02 and 14:01.

Frontiers in immunology - 1 Jan 2026

Toraman Bayram, Kasap Burak Kaan, Ermis Hande, Arica Deniz Aksu, Yayli Savaş

Abstract excerpt

Introduction: Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune blistering disease characterized by autoantibodies directed against the desmosomal cadherins desmoglein 3 (DSG3) and desmoglein 1 (DSG1), which are essential for keratinocyte adhesion. While the pathogenic role of these autoantibodies is well established, the upstream events leading to loss of immune tolerance against desmogleins...

Topics

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Autoantibodies
Cadherins
Computer Simulation
Desmoglein 1
HLA-DRB1 Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Dynamics Simulation

Molecular Mimicry

Source

Open in PubMed Open full text

Identifiers

PMID: 41789085
DOI: 10.3389/fimmu.2026.1745207
PMCID: PMC12956788

Genes

DSG3
DSG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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