Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

25 Sept 2012

Abstract excerpt

Pemphigus vulgaris (PV) is an autoimmune blistering disease of skin and mucous membranes caused by autoantibodies to the desmoglein (DSG) family proteins DSG3 and DSG1, leading to loss of keratinocyte cell adhesion. To learn more about pathogenic PV autoantibodies, we isolated 15 IgG antibodies specific for DSG3 from 2 PV patients. Three antibodies disrupted keratinocyte monolayers in vitro, and 2 were pathogenic...

Topics

Join the communities discussing this publication.

Autoimmune Bullous Skin Diseases
Coagulation, Bradykinin, Polyphosphates, and Angioedema
Urticaria and Related Conditions

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22996451
DOI: 10.1172/jci64413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interfacePMID 22996451Read ↗

IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris.Semantic proximity Read ↗

Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice.Semantic proximity Read ↗

Analysis of the T cells that are potentially involved in autoantibody production in pemphigus vulgaris.Semantic proximity Read ↗

Immune response in pemphigus and beyond: progresses and emerging concepts.Semantic proximity Read ↗

Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions.Semantic proximity Read ↗

Autoantibody-Specific Signalling in PemphigusSemantic proximity Read ↗

Conformational epitope mapping of antibodies against desmoglein 3 in experimental murine pemphigus vulgaris.Semantic proximity Read ↗

Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.Semantic proximity Read ↗

Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies.Semantic proximity Read ↗

Vector-derived Cadherin Mimicry in Pemphigus Vulgaris: A Proposed Model Linking HLA-DRB1*04:02/14:01 Genotype with Environmental ExposureSemantic proximity Read ↗

Autoantibody Signaling in Pemphigus Vulgaris: Development of an Integrated ModelSemantic proximity Read ↗

IgG reactivity against non-conformational NH-terminal epitopes of the desmoglein 3 ectodomain relates to clinical activity and phenotype of pemphigus vulgaris.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.