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Article

Population pharmacokinetics of lamotrigine co-administered with valproic acid in Chinese epileptic children using nonlinear mixed effects modeling.

European journal of clinical pharmacology - 1 May 2018

Xu Shansen, Liu Limin, Chen Yanan, Liu Mei, Lu Tong, Wang Huanxin, Liu Shihao, Zhao Mingming, Zhao Limei

Abstract excerpt

PURPOSE: The aims of this study were to develop a population pharmacokinetic (PPK) model of lamotrigine (LTG) in Chinese epileptic children by using nonlinear mixed effects modeling (NONMEM) and to investigate the effects of valproic acid (VPA) and genetic polymorphisms of the major metabolizing enzymes (UGT1A4, UGT2B7) on the pharmacokinetics of LTG. METHODS: A total of 182 epileptic children who were treated...

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Source

Identifiers

PMID: 29340733
DOI: 10.1007/s00228-018-2414-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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