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Article

Comparative GWAS using global and Indian Reference Panels reveals non-coding drivers of COVID-19 severity and mortality.

PLoS neglected tropical diseases - 1 Mar 2026

Kaushik Aastha, Mohite Ramakant, Maurya Ranjeet, Tarai Bansidhar, Budhiraja Sandeep, Shamim Uzma, Pandey Rajesh

Abstract excerpt

India remains underrepresented in global genomic studies. We hypothesized that population-specific genetic variants contribute to COVID-19 severity and outcomes, and that the choice of reference panel during imputation impacts Genome-Wide Association Studies (GWAS) resolution. Integrating both global and indigenous reference panels may unravel unique and shared genetic associations that are otherwise missed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41774713
DOI: 10.1371/journal.pntd.0014020
PMCID: PMC12956133

Genes

BMP1
SFTPC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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