Article

Gene-environment interaction between VDR variants and vitamin D deficiency identifies a high-risk inflammatory phenotype associated with COVID-19 severity

2026-08-13

Abstract excerpt

Abstract Host determinants of inflammatory escalation remain incompletely defined in COVID-19. Vitamin D receptor (VDR) signaling regulates immune activation and cytokine responses, yet the contribution of VDR genetic variation to severe disease is unclear. We investigated two common VDR polymorphisms (rs7975232 and rs1544410) in a prospective, clinically stratified Indian cohort ( n = 323), integrating genotype–p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce9ad9a0-b3cb-50eb-a7d4-16ac599af5c2
DOI: 10.1038/s41598-026-63315-3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene-environment interaction between VDR variants and vitamin D deficiency identifies a high-risk inflammatory phenotype associated with COVID-19 severityDOI 10.1038/s41598-026-63315-3Read

Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients.Semantic proximity Read

Single-nucleotide polymorphisms related to vitamin D metabolism and severity or mortality of COVID-19: A systematic review and meta-analysis.Semantic proximity Read

The Association of Vitamin D Receptor Polymorphisms with COVID-19 Severity.Semantic proximity Read

Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents.Semantic proximity Read

Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysis.Semantic proximity Read

Genetically predicted serum vitamin D and COVID-19: a Mendelian randomization studySemantic proximity Read

Potential Genes Associated with COVID-19 and Comorbidity.Semantic proximity Read

An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D.Semantic proximity Read

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study.Semantic proximity Read