Article

Genetic proxies for clinical traits are associated with increased risk of severe COVID-19

2023-07-31

Abstract excerpt

<title>Abstract</title> <p>Routine use of genetic data in healthcare is much-discussed, yet little is known about its performance in epidemiological models including traditional risk factors. Using severe COVID-19 as an exemplar, we explore the integration of polygenic risk scores (PRS) into disease models alongside sociodemographic and clinical variables. PRS were optimized for 23 clinical variables and related...

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Literature Corpus work: c9798b30-2a5b-5009-a5f6-84a414b88fcb
DOI: 10.21203/rs.3.rs-3181821/v1

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