Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy.

Investigative ophthalmology & visual science - 1 Oct 2017

Zhou Guohong, Duan Yajiang, Ma Gaoen, Wu Wenyi, Hu Zhengping, Chen Na, Chee Yewlin, Cui Jing, Samad Arif, Matsubara Joanne A, Mukai Shizuo, D'Amore Patricia A, Lei Hetian

Abstract excerpt

Purpose: The murine double minute (MDM)2 is a critical negative regulator of the p53 tumor suppressor, and MDM2 SNP309G is associated with a higher risk of proliferative vitreoretinopathy (PVR); in addition, the MDM2 T309G created using clustered regularly interspaced short palindromic repeats (CRISPR)/associated endonuclease (Cas)9 enhances normal rabbit vitreous-induced expression of MDM2 and survival of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to Clustered Regularly Interspaced Short Palindromic Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intravitreal Injections

Share to Proto-Oncogene Proteins c-mdm2

Share to Rabbits

Share to Real-Time Polymerase Chain Reaction

Share to Retinal Pigment Epithelium

Share to Vitreous Body

Source

Open in PubMed Open full text

Identifiers

PMID: 29049737
DOI: 10.1167/iovs.17-22045
PMCID: PMC5649510

Genes

MDM2
PVR
RPE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy.PMID 29049737Read ↗

The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells.Semantic proximity Read ↗

The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy.Semantic proximity Read ↗

A diabetes-induced change of MDM2 SNP309T→G contributes to aberrant retinal angiogenesis.Semantic proximity Read ↗

CRISPR/Cas9 mediated specific ablation of vegfa in retinal pigment epithelium efficiently regresses choroidal neovascularizationSemantic proximity Read ↗

The Evolving Story of PterygiumSemantic proximity Read ↗

p53 E3 ubiquitin protein ligase homolog regulates p53 in vivo in the adult mouse eye lens.Semantic proximity Read ↗

Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.Semantic proximity Read ↗

Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative VitreoretinopathySemantic proximity Read ↗

Role of inhibitors of isoprenylation in proliferation, phenotype and apoptosis of human retinal pigment epithelium.Semantic proximity Read ↗

Inhibitory Effect of MicroRNA-34a on Retinal Pigment Epithelial Cell Proliferation and MigrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.