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Article

Bidirectional Mendelian randomization analysis of the relationships between blood cell phenotypes, genetic variants, and systemic lupus erythematosus.

Medicine - 27 Feb 2026

Wei Ju, Liang Hu

Abstract excerpt

Based on a bidirectional two-sample Mendelian randomization (MR) analysis of 91 blood cell phenotypes and systemic lupus erythematosus (SLE), this study provides genetic evidence for a complex causal interplay between specific immune cell functions and SLE susceptibility. Forward MR analysis identified 4 perturbation responses - involving eosinophils (response to colchicine), neutrophils (response to potassium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41760022
DOI: 10.1097/MD.0000000000047906
PMCID: PMC12956214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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