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Article

Causal Effect of Blood Cell Perturbation Phenotypes on Multiple Sclerosis via Immune Mediation: A Mendelian Randomization Study.

Cellular and molecular neurobiology - 25 Oct 2025

Yun Jia-Jia, Wang Jin-Qiu, Wang Jia-Hui, Wang Zhen, Li Ya-Lei, Yang Yu, Chen Fang-Min, Ren Chao

Abstract excerpt

Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system, characterized by myelin damage caused by immune dysfunction and genetic factors. Nevertheless, the role of peripheral blood and immune cells in the development of MS remains poorly defined. We employed a two-sample Mendelian randomization (MR) approach, analyzing data from 91 blood cell perturbation phenotypes and 731...

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Topics

Humans
Mendelian Randomization Analysis
Multiple Sclerosis
Phenotype
Blood Cells
Genetic Predisposition to Disease

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Causality

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Identifiers

PMID: 41137998
DOI: 10.1007/s10571-025-01617-2
PMCID: PMC12553782

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