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Article

Aneuploidy alleviates the cell proliferation defect caused by mutations affecting origin licensing in Saccharomyces cerevisiae.

PLoS genetics - 1 Feb 2026

de La Roche Saint-André Christophe

Abstract excerpt

Although aneuploidy is generally detrimental to the survival and growth of normal cells, it can be beneficial under certain stress conditions, such as those caused by harmful mutations. In Saccharomyces cerevisiae, we find that duplication of chromosome III accelerates cell proliferation in the orc5-1 mutant. Enhanced proliferation is also observed when a fragment from a different chromosome is introduced,...

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Identifiers

PMID: 41758868
DOI: 10.1371/journal.pgen.1012063
PMCID: PMC12965678

Genes

CLN3

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