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Article

Hepatocyte-Specific Knockout of YAP Protects Against Atherosclerosis via Inhibition of ANGPTL3 in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2026

Hou Ying, Zhang Xin, Sun Xia, Qin Qiaohong, Jia Min, Su Xingli, Chen Yulong

Abstract excerpt

BACKGROUND: Lipid-lowering therapy is a cornerstone in the treatment of atherosclerotic cardiovascular diseases. Although some lipid-lowering drugs have demonstrated positive effects in patients with atherosclerotic cardiovascular diseases, their effects are limited in those with homozygous familial hypercholesterolemia. It is essential to seek new lipid-lowering targets. YAP (Yes-associated protein) may be...

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Identifiers

PMID: 41744066
DOI: 10.1161/ATVBAHA.125.324122

Genes

LDLR
ANGPTL3
TEAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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