Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.

doi:10.1126/sciadv.1602096

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Article

Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.

Science advances - 1 Mar 2017

Wang Liuyang, Ko Emily R, Gilchrist James J, Pittman Kelly J, Rautanen Anna, Pirinen Matti, Thompson J Will, Dubois Laura G, Langley Raymond J, Jaslow Sarah L, Salinas Raul E, Rouse D Clayburn, Moseley M Arthur, Mwarumba Salim, Njuguna Patricia, Mturi Neema, Williams Thomas N, Scott J Anthony G, Hill Adrian V S, Woods Christopher W, Ginsburg Geoffrey S, Tsalik Ephraim L, Ko Dennis C

Abstract excerpt

Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis, prognosis, and treatment. Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salvage pathway is a regulator of sepsis that can accurately predict prognosis in patients. Pathway-based genome-wide...

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PMID: 28345042
DOI: 10.1126/sciadv.1602096
PMCID: PMC5342653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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