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Article

CD146 + interstitial cells contribute to the dystrophic skeletal muscle phenotype in vitro.

Scientific reports - 24 Feb 2026

Mierzejewski Bartosz, Michalska Zuzanna, Kulma Dominika, Bos Aleksandra, Streminska Wladyslawa, Bartoszewicz Zbigniew, Brzoska Edyta

Abstract excerpt

CD146 + interstitial cells are myogenic progenitors which contribute to skeletal muscle regeneration. However, their role in Duchenne muscular dystrophy (DMD) remains unclear. We compared CD146 + cells from wild-type and mdx mice, revealing distinct molecular and functional differences. Mdx CD146 + differentiated less efficiently into myoblasts and multinucleated myotubes but more efficiently into fibroblasts and...

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Identifiers

PMID: 41735360
DOI: 10.1038/s41598-026-38311-2
PMCID: PMC13031678

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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