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Article

Involvement of Multiple Variants of Soluble <scp>CD146</scp> in Systemic Sclerosis: Identification of a Novel Profibrotic Factor

9 Jan 2022

Abstract excerpt

OBJECTIVE: Systemic sclerosis (SSc) is an autoimmune disorder characterized by excessive fibrosis, immune dysfunction, and vascular damage, in which the expression of many growth factors is deregulated. CD146 was recently described as a major actor in SSc. Since CD146 also exists as a circulating soluble form (sCD146) that acts as a growth factor in numerous angiogenic- and inflammation-related pathologies, we...

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PMID: 35001552
DOI: 10.1002/art.42063

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