Article
Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2013
Palladino Mariangela, Gatto Ilaria, Neri Valentina, Straino Stefania, Smith Roy C, Silver Marcy, Gaetani Eleonora, Marcantoni Margherita, Giarretta Igor, Stigliano Egidio, Capogrossi Maurizio, Hlatky Lynn, Landolfi Raffaele, Pola Roberto
Abstract excerpt
OBJECTIVE: Dystrophin, the missing or defective protein in Duchenne muscular dystrophy, is expressed not only in muscle cells but also in vascular endothelial cells (ECs). In this study, we assessed the effects of dystrophin deficiency on the angiogenic capacities of ECs. APPROACH AND RESULTS: We isolated vascular ECs from mdx mice, the murine equivalent of Duchenne muscular dystrophy in humans, and wild-type...
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