Article
Analyses of rare predisposing variants of lung cancer in 6,004 whole genomes in Chinese.
Cancer cell - 10 Oct 2022
Wang Cheng, Dai Juncheng, Qin Na, Fan Jingyi, Ma Hongxia, Chen Congcong, An Mingxing, Zhang Jing, Yan Caiwang, Gu Yayun, Xie Yuan, He Yuanlin, Jiang Yue, Zhu Meng, Song Ci, Jiang Tao, Liu Jia, Zhou Jun, Wang Nanxi, Hua Tingting, Liang Shuang, Wang Lu, Xu Jing, Yin Rong, Chen Liang, Xu Lin, Jin Guangfu, Lin Dongxin, Hu Zhibin, Shen Hongbing
Abstract excerpt
We present the largest whole-genome sequencing (WGS) study of non-small cell lung cancer (NSCLC) to date among 6,004 individuals of Chinese ancestry, coupled with 23,049 individuals genotyped by SNP array. We construct a high-quality haplotype reference panel for imputation and identify 20 common and low-frequency loci (minor allele frequency [MAF] ≥ 0.5%), including five loci that have never been reported...
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