Article
Promoter hypermethylation along with LOH, but not mutation, contributes to inactivation of DLC-1 in nasopharyngeal carcinoma.
Molecular carcinogenesis - 1 Nov 2014
Feng Xiangling, Ren Caiping, Zhou Wen, Liu Weidong, Zeng Liang, Li Guifei, Wang Lei, Li Min, Zhu Bin, Yao Kaitai, Jiang Xingjun
Abstract excerpt
Previous studies have shown that promoter hypermethylation plays a key role in DLC-1 inactivation in nasopharyngeal carcinoma (NPC). However, DLC-1 mutation in NPC has not been reported, and there remain some discrepancies in methods and results between different groups. Here, we examined the mRNA and protein expression of DLC-1 in chronic nasopharyngitis (CN) and NPC tissues by reverse transcription-polymerase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.