Article
Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer.
Cell calcium - 1 Mar 2022
Gao San-Hui, Wang Gui-Zhen, Wang Li-Peng, Feng Lin, Zhou Yong-Chun, Yu Xian-Jun, Liang Fan, Yang Fu-Ying, Wang Zheng, Sun Bei-Bei, Wang Di, Liang Li-Jun, Xie Da-Wei, Zhao Song, Feng Hai-Ping, Li Xueqing, Li Keqin Kathy, Tang Tie-Shan, Huang Yun-Chao, Wang Shi-Qiang, Zhou Guang-Biao
Abstract excerpt
CACNA1E is a gene encoding the ion-conducting α1 subunit of R-type voltage-dependent calcium channels, whose roles in tumorigenesis remain to be determined. We previously showed that CACNA1E was significantly mutated in patients with non-small cell lung cancer (NSCLC) who were long-term exposed to household air pollution, with a mutation rate of 19% (15 of 79 cases). Here we showed that CACNA1E was also mutated...
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