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Article

Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis-Application in a Real-World Setting.

Human psychopharmacology - 1 Mar 2026

Heald Adrian, Illangasekera Yasitha, Loureiro Camila Marcelino, Shakespeare Mark, Jameson Adam, Phillipson Adrian, Reynolds Gavin P, Dalton Caroline

Abstract excerpt

INTRODUCTION: Genetic factors are thought to play an important role in antipsychotic-induced weight gain (AIWG). Polygenic risk scores (PRS) could provide a measure of genetic predisposition to antipsychotic drug induced weight gain (AIWG).We conducted a study to examine how a PRS, generated using SNPs, identified from a recent meta-analysis, related to weight-change over time in people with first...

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Identifiers

PMID: 41831324
DOI: 10.1002/hup.70035
PMCID: PMC12988834

Genes

ADRA2A
CNR1
HTR2C
LEPR
MC4R
MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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