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Article

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes.

Clinical pharmacology and therapeutics - 1 Oct 2026

Breeyear Joseph H, House John S, Kvale Mark, Nam Stella, Akhtari Farida S, Shah Hetal S, Hedderson Monique M, Giacomini Kathleen M, Mychaleckyj Josyf C, Doria Alessandro, Wagner Michael J, Li Josephine H, Yee Sook Wah, Buse John B, Woychik Richard P, Rotroff Daniel M, Motsinger-Reif Alison A

Abstract excerpt

Sulfonylureas are a cornerstone of type 2 diabetes therapy despite interindividual variability in response. Despite well-documented sex-based differences, pharmacogenomic and genome-wide association studies (GWAS) have largely overlooked sex as a biological variable. We conducted the first sex-stratified GWAS of hemoglobin A1c (HbA1c) response to sulfonylureas in Action to Control Cardiovascular Risk in Diabetes...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Male
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Sulfonylurea Compounds

Hypoglycemic Agents

Metformin

Middle Aged

Sex Factors

Glycated Hemoglobin

Treatment Effect Heterogeneity

Blood Glucose

Insulin Secretagogues

Insulin

Aged

Glipizide

Pharmacogenetics

Source

Open in PubMed Open full text

Identifiers

PMID: 42504935
DOI: 10.1002/cpt.70381
PMCID: PMC13403371

Genes

CRACR2A
KAZN
KCNK2
KIF2B
NECAB1
SLC39A10
SPINK5
TENM2
TMEM64

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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