Integration of TWAS with single-cell and spatial transcriptomics identifies TLR1 as a susceptibility gene and therapeutic target in the breast cancer tumor microenvironment.

Abstract excerpt

Breast cancer is a common malignant tumor with a complex pathogenesis, and while genome-wide association studies (GWAS) have identified multiple risk loci, they often fall short in pinpointing specific functional susceptibility genes. To address this, we collected whole-tissue eQTL data from the GTEx portal and breast cancer GWAS summary data from the Breast Cancer Association Consortium (BCAC) and FinnGen R10...

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