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Article

CBFA2T2: a novel H3K27 reader regulating metabolism and tumor growth.

Molecular cancer - 17 Feb 2026

He Shengfei, Ou Yutian, Jiao Fangfang, Feng Jiuxing, Zhu Ping, Ma Jie, Xu Ning, Li Haitao, Guo Rui

Abstract excerpt

Histone H3.3K27M mutations are identified in diffuse midline glioma (DMG), resulting in a global reduction in H3K27me3. Analyzing the histone recognition mechanism at H3K27 position can enhance the understanding of this highly lethal mutation. Here we identify a novel histone reader CBFA2T2, which recognizes non-mutated or un-modified histone H3K27. Biochemical assays confirm this binding specificity, indicating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41703542
DOI: 10.1186/s12943-026-02593-x
PMCID: PMC13081504

Genes

CBFA2T2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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