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Article

Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment.

JCI insight - 8 Feb 2022

Trautwein Christoph, Zizmare Laimdota, Mäurer Irina, Bender Benjamin, Bayer Björn, Ernemann Ulrike, Tatagiba Marcos, Grau Stefan J, Pichler Bernd J, Skardelly Marco, Tabatabai Ghazaleh

Abstract excerpt

The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present an unprecedented and valuable resource for tissue metabolites in diffuse glioma and their modulations by IDH1...

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Identifiers

PMID: 34941573
DOI: 10.1172/jci.insight.153526
PMCID: PMC8855807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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