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Article

Bidirectional Genetic Control of Phenotypic Heterogeneity and Its Implication for Cancer Drug Resistance.

Molecular biology and evolution - 4 May 2021

Mo Ning, Zhang Xiaoyu, Shi Wenjun, Yu Gongwang, Chen Xiaoshu, Yang Jian-Rong

Abstract excerpt

Negative genetic regulators of phenotypic heterogeneity, or phenotypic capacitors/stabilizers, elevate population average fitness by limiting deviation from the optimal phenotype and increase the efficacy of natural selection by enhancing the phenotypic differences among genotypes. Stabilizers can presumably be switched off to release phenotypic heterogeneity in the face of extreme or fluctuating environments to...

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PMID: 33355660
DOI: 10.1093/molbev/msaa332
PMCID: PMC8097262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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