Article

LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

2024-03-13

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emerging research suggests that dysfunction of the nuclear envelope (NE) may contribute to disease pathogenesis and progression. The NE plays a role in ALS through several mechanis...

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Literature Corpus work: 3968a3b7-c861-581e-983d-17bb7bcb5c5c
DOI: 10.1101/2024.03.08.584123

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