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Article

Aberrant distributions of nuclear pore complex proteins in ALS mice and ALS patients.

Neuroscience - 14 May 2017

Shang Jingwei, Yamashita Toru, Nakano Yumiko, Morihara Ryuta, Li Xianghong, Feng Tian, Liu Xia, Huang Yong, Fukui Yusuke, Hishikawa Nozomi, Ohta Yasuyuki, Abe Koji

Abstract excerpt

Nuclear pore complexes (NPCs) play important roles in traffic of molecules between the nucleus and cytoplasm, aberrant distributions of components of NPCs were demonstrated in C9orf72 amyotrophic lateral sclerosis (C9-ALS) patients, but it is elusive whether such abnormities are also the case with other cause of ALS disease. In the present study, we investigated the spatiotemporal distributions of RanGAP1 and 4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28344074
DOI: 10.1016/j.neuroscience.2017.03.024

Genes

SOD1
NUP50

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