Article

FVIII interacts with cell surface to regulate endothelial cell functionality

2023-10-19

Abstract excerpt

Haemophilia A (HA) is a rare bleeding disorder caused by factor 8 (F8) mutations. Clinical manifestations are spontaneous bleedings that primarily consist of hemarthrosis and intracranial haemorrhages. To date, the impairment of vessel stability in HA patients and the correlation between FVIII and endothelial functionality is poorly understood. Here we show that FVIII plays a role in endothelial cell functionality...

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Literature Corpus work: b46cc459-d9c1-5ea0-b0ce-c32491f69c93
DOI: 10.1101/2023.10.19.563105

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