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Prevalence and Prognostic Impact of NPM1 Mutation in Childhood Acute Myeloid Leukemia: Experience from a Single Tertiary Cancer Centre in India.

Clinical lymphoma, myeloma & leukemia - 1 Mar 2026

Srinivasan Shyam, Aggarwal Mili, Patkar Nikhil, Gurjar Poorva, Dhamne Chetan, Moulik Nirmalya Roy, Chichra Akanksha, Chatterjee Gaurav, Rajpal Sweta, Tembhare Prashant, Shetty Dhanalaxmi, Subramanian Papagudi G, Narula Gaurav, Banavali Shripad

Abstract excerpt

BACKGROUND AND AIMS: Nucleophosmin (NPM1) mutations are associated with favorable outcomes in adults; however, their prognostic relevance in pediatric acute myeloid leukemia (AML) remains unclear due to their rarity. This single center study from India, investigates the prevalence and prognostic impact of NPM1-mutated childhood AML. METHODS: Patients less than 15 years of age with newly diagnosed AML treated...

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Identifiers

PMID: 41238479
DOI: 10.1016/j.clml.2025.10.015

Genes

NPM1
FLT3
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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