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Article

The impact of antioxidant-ciprofloxacin combinations on the evolution of antibiotic resistance in Pseudomonas aeruginosa biofilms.

NPJ biofilms and microbiomes - 30 Dec 2024

Higazy Doaa, Ahmed Marwa N, Ciofu Oana

Abstract excerpt

The evolution of antimicrobial resistance (AMR) in biofilms, driven by mechanisms like oxidative stress, is a major challenge. This study investigates whether antioxidants (AOs) such as N-acetyl-cysteine (NAC) and Edaravone (ED) can reduce AMR in Pseudomonas aeruginosa biofilms exposed to sub-inhibitory concentrations of ciprofloxacin (CIP). In vitro experimental evolution studies were conducted using flow cells...

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Identifiers

PMID: 39738092
DOI: 10.1038/s41522-024-00640-3
PMCID: PMC11685532

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