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Article

Characterizing the polygenic overlap and shared loci between rheumatoid arthritis and cardiovascular diseases.

BMC medicine - 8 Apr 2024

Sun Xiaohui, Qian Yu, Cheng Weiqiu, Ye Ding, Liu Bin, Zhou Dan, Wen Chengping, Andreassen Ole A, Mao Yingying

Abstract excerpt

BACKGROUND: Despite substantial research revealing that patients with rheumatoid arthritis (RA) have excessive morbidity and mortality of cardiovascular disease (CVD), the mechanism underlying this association has not been fully known. This study aims to systematically investigate the phenotypic and genetic correlation between RA and CVD. METHODS: Based on UK Biobank, we conducted two cohort studies to evaluate...

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Source

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Identifiers

PMID: 38589871
DOI: 10.1186/s12916-024-03376-1
PMCID: PMC11003061

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