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Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance

1 Apr 2022

Abstract excerpt

Postpartum depression (PPD) affects 1 in 7 women and has negative mental health consequences for both mother and child. However, the precise biological mechanisms behind the disorder are unknown. Therefore, we performed the largest transcriptome-wide association study (TWAS) for PPD (482 cases, 859 controls) to date using RNA-sequencing in whole blood and deconvoluted cell types. No transcriptional changes were...

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PMID: 35365803
DOI: 10.1038/s41380-022-01525-7

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