Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of molecular profiling on the management of patients with myelofibrosis.

Cancer treatment reviews - 1 Sept 2022

Pastor-Galán Irene, Martín Iván, Ferrer Blanca, Hernández-Boluda Juan-Carlos

Abstract excerpt

Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MPN) characterized by a highly heterogeneous clinical course, which can be complicated by severe constitutional symptoms, massive splenomegaly, progressive bone marrow failure, cardiovascular events, and development of acute leukemia. Constitutive signaling through the JAK-STAT pathway plays a fundamental role in its pathogenesis, generally due to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Janus Kinase 2
Share to Janus Kinases
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloproliferative Disorders

Share to Primary Myelofibrosis

Share to Receptors, Thrombopoietin

Share to Signal Transduction

Share to STAT Transcription Factors

Source

Identifiers

PMID: 35839532
DOI: 10.1016/j.ctrv.2022.102435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of molecular profiling on the management of patients with myelofibrosis.PMID 35839532Read ↗

Molecular Genetic Profile of Myelofibrosis: Implications in the Diagnosis, Prognosis, and Treatment AdvancementsSemantic proximity Read ↗

Progress in elucidation of molecular pathophysiology of myeloproliferative neoplasms and its application to therapeutic decisions.Semantic proximity Read ↗

Mutation profiling of chronic myeloproliferative neoplasms: improving clinical-molecular prognostic models.Semantic proximity Read ↗

The Role and Impact of Non-driver Gene Mutations in Myelofibrosis.Semantic proximity Read ↗

Myeloproliferative neoplasms: updates on molecular pathophysiology, diagnosis and treatment strategies.Semantic proximity Read ↗

Recent insights regarding the molecular basis of myeloproliferative neoplasms.Semantic proximity Read ↗

Detection of driver and subclonal mutations in myelofibrosis: clinical impact on pharmacologic and transplant based treatment strategies.Semantic proximity Read ↗

What Do Molecular Tests Add to Prognostic Stratification in MF: Is It Time to Add These to Our Clinical Practice?Semantic proximity Read ↗

Myelofibrosis: Genetic Characteristics and the Emerging Therapeutic Landscape.Semantic proximity Read ↗

Prognosis of Primary Myelofibrosis in the Genomic Era.Semantic proximity Read ↗

Impact of Mutational Profile on the Management of Myeloproliferative Neoplasms: A Short Review of the Emerging DataSemantic proximity Read ↗

Molecular profiling in MPN: who should have it and why?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.