Article
Mendelian Randomization Analysis Identified Potential Genes Pleiotropically Associated with Polycystic Ovary Syndrome.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Mar 2022
Sun Qian, Gao Yuan, Yang Jingyun, Lu Jiayi, Feng Wen, Yang Wen
Abstract excerpt
Polycystic ovary syndrome (PCOS) is a common endocrine disorder with unclear etiology. Some genes may be pleiotropically or potentially causally associated with PCOS. In the present study, the summary data-based Mendelian randomization (SMR) method integrating genome-wide association study (GWAS) for PCOS and expression quantitative trait loci (eQTL) data was applied to identify genes that were pleiotropically...
Topics
- DNA Glycosylases
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mendelian Randomization Analysis
- Polycystic Ovary Syndrome
- Quantitative Trait Loci
- Ribosomal Proteins