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Article

Integrative multi-omics Mendelian randomization reveals key lipid metabolism genes as therapeutic targets for diabetic nephropathy pathogenesis.

Renal failure - 1 Dec 2026

Liu Shan, Xia Yan, Ding Lin, Zhang Mingxia, Wang Wangzhen, Zhou Junying, Liu Lunzhi

Abstract excerpt

Dysregulated lipid metabolism contributes to diabetic nephropathy (DN), but the genetic links remain unclear. This study identified lipid metabolism genes associated with DN risk using summary-data-based Mendelian randomization (SMR). SMR screened 757 lipid metabolism genes by integrating large-scale blood methylation quantitative trait locus (mQTL; n = 1,980), expression QTL (eQTL; n = 31,684), and protein QTL...

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Share to 1-Alkyl-2-acetylglycerophosphocholine Esterase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42219961
DOI: 10.1080/0886022X.2026.2671460
PMCID: PMC13228183

Genes

CERS2
MED27
PLA2G1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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