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Article

Molecular mechanism of action of small molecule SMT-738 on bacterial lipoprotein transporter LolCDE.

Nature communications - 9 Feb 2026

Li Haotian, Zhu Xiaojing, Zhang Dongdong, Duan Xiaofeng, Li Jiahui, Qu Yao, Li Danyang, Zhang Zhengyu, Dong Haohao, Guo Feng-Biao, Dong Changjiang

Abstract excerpt

SMT-738 is a small molecule with promising antibacterial activity against Enterobacteriaceae, including multi-drug-resistant Escherichia coli. Mutations in genes encoding the lipoprotein transport complex (LolCDE) confer resistance to SMT-738. Here, we report the cryogenic electron microscopy structure of the LolCDE-SMT-738 complex at a high resolution. We use mutagenesis, drug resistance assays, biochemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41663437
DOI: 10.1038/s41467-026-69411-2
PMCID: PMC13000274

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