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Article

Small-molecule inhibitors of gram-negative lipoprotein trafficking discovered by phenotypic screening.

Journal of bacteriology - 1 Mar 2015

McLeod Sarah M, Fleming Paul R, MacCormack Kathleen, McLaughlin Robert E, Whiteaker James D, Narita Shin-Ichiro, Mori Makiko, Tokuda Hajime, Miller Alita A

Abstract excerpt

In Gram-negative bacteria, lipoproteins are transported to the outer membrane by the Lol system. In this process, lipoproteins are released from the inner membrane by the ABC transporter LolCDE and passed to LolA, a diffusible periplasmic molecular chaperone. Lipoproteins are then transferred to the outer membrane receptor protein, LolB, for insertion in the outer membrane. Here we describe the discovery and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25583975
DOI: 10.1128/JB.02352-14
PMCID: PMC4336340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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