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Article

A Novel Inhibitor of the LolCDE ABC Transporter Essential for Lipoprotein Trafficking in Gram-Negative Bacteria.

Antimicrobial agents and chemotherapy - 1 Apr 2018

Nickerson Nicholas N, Jao Christine C, Xu Yiming, Quinn John, Skippington Elizabeth, Alexander Mary Kate, Miu Anh, Skelton Nicholas, Hankins Jessica V, Lopez Michael S, Koth Christopher M, Rutherford Steven, Nishiyama Mireille

Abstract excerpt

The outer membrane is an essential structural component of Gram-negative bacteria that is composed of lipoproteins, lipopolysaccharides, phospholipids, and integral β-barrel membrane proteins. A dedicated machinery, called the Lol system, ensures proper trafficking of lipoproteins from the inner to the outer membrane. The LolCDE ABC transporter is the inner membrane component, which is essential for bacterial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29339384
DOI: 10.1128/AAC.02151-17
PMCID: PMC5913989

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