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Article

Causal Mediation Role of Immune Cells in Gut Microbiota-Pneumonia Associations: A Mendelian Randomisation Study.

Journal of cellular and molecular medicine - 1 Sept 2025

Hou Nianzong, Zhang Zhenhong, Song Weiwei, Wang Lin, Xu Guoxiang, Zhang Rumin, Yang Yulong, Wang Kai

Abstract excerpt

The gut-lung axis plays a pivotal role in pneumonia pathogenesis, with immune regulation serving as a key mechanistic link between gut microbiota and disease progression. Despite established associations among gut microbiota, immune cell traits and pneumonia, their causal interplay and underlying mechanisms remain poorly elucidated. To investigate the causal relationships between gut microbiota and pneumonia and...

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PMID: 40936181
DOI: 10.1111/jcmm.70839
PMCID: PMC12425809

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