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Article

The MTHFR C677T genetic susceptibility and its role in risk prediction for type 2 diabetic nephropathy in Northern China.

Frontiers in endocrinology - 1 Jan 2026

Song Junli, Zhang Juanjuan, Guo Qian, Zhao Qiang

Abstract excerpt

Objective: Diabetic nephropathy is a diabetes-induced chronic kidney disease characterized by pathological changes that may involve the entire renal structure and can progress to end-stage renal disease, thereby substantially impairing patients' quality of life. The MTHFR C677T gene polymorphism has been closely associated with the development of diabetic nephropathy through its regulatory effect on homocysteine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41648721
DOI: 10.3389/fendo.2026.1749477
PMCID: PMC12867841

Genes

MTHFR
ACR
TG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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The MTHFR C677T genetic susceptibility and its role in risk prediction for type 2 diabetic nephropathy in Northern China.PMID 41648721Read ↗

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