Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus.

doi:10.3109/0886022X.2015.1064743

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Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus.

Renal failure - 1 Jan 2015

Zhou Tian-Biao, Drummen Gregor P C, Jiang Zong-Pei, Li Hong-Yan

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme that regulates nucleotide synthesis and DNA methylation. The MTHFR C677T gene polymorphism (rs1801133), a C → T transition at nucleotide 677 in exon 4, is a common gene variant of MTHFR and has been implicated in diabetic nephropathy, albeit with inconsistent results. Here, we performed a meta-analysis to assess the common effect size of this...

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PMID: 26161693
DOI: 10.3109/0886022X.2015.1064743

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MTHFR

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